Pythons' reunion is off to a flying start in the O2
One of the first classic sketches they performed was the four Yorkshiremen comparing their tough upbringing. The sell-out crowd included celebrity guests such as Stephen Fry.
The audience were also treated to clips from the old shows including the fish-slapping sketch.
Michael Palin got a great ovation for his performance of The Lumberjack Song complete with an advert inviting tourists to visit Canada for its "elks". Some of the biggest cheers of the night were reserved for archive clips featuring Graham Chapman and the audience were treated to the philosopher's song.
The second half of the show kicked off with a spoof ballet, Spam Lake, before a performance of the X-rated Sit on my Face song. Fry turned up on stage later in the night during a sketch about a game show host blackmailing misbehaving celebrities.