Niall Horan faces off against Perry and Bieber at MTV Europe Awards
The chart-topping boyband, comprising Horan, Zayn Malik, Liam Payne, Harry Styles and Louis Tomlinson, have been nominated for three awards including Best Pop, Biggest Fans and Best UK and Ireland Act.
Rudimental are also up for three nominations, including Best New Act and Best UK and Ireland Act.
US rapper Eminem is set to be honoured with the Global Icon prize on the night, which he will receive in person.
The singer revealed he is most excited about Cyrus's performance. She has previously made headlines for "twerking" in a skin-coloured latex bikini with Robin Thicke at the MTV Video Music Awards.
"I want to see what she's going to do. I haven't seen her in rehearsals because I want to be just as shocked as everyone else," he said.