The Rise Of The Guardians actress, who married the British comic in March 2010, revealed his personas - including Borat, Bruno and The Dictator's Admiral General Aladeen - have become a "part of life".
"I've lived with a handlebar moustache, I've lived with the Justin Bieber hair flick, I've lived with The Dictator finger. He's writing at the moment, so I'm living with a writer. His personas are definitely a part of life," she said.
While the 36-year-old enjoys her husband's work, the pair have no plans to work together on screen in the near future.
"I'm a huge fan of what he does but we work together in so many other areas in our life that I'm quite happy to do my own thing and have him do his own thing," she explained.
Isla - who voices the Tooth Fairy in Rise Of The Guardians - admitted that her husband's faux pas are "really fabulous" especially when they're out at glitzy events.
"And then there was one time when Jack Black invited us to a screening. This rather heavy-set lady with really big boobs stood up and gave a really long speech, and at the end of the movie, Jack said 'Thanks for coming'.
"But then Sacha goes to Jack: 'This is a great movie! Why'd you make such a short speech? You should have shut up that lady with the massive t**s who wouldn't stop talking'. Jack said, 'That's my mother!'."
:: Rise Of The Guardians opens in cinemas on November 30.