Josh Duhamel is in talks to star in drama You're Not You.
Emmy is already on board to play a "self-absorbed college student" who becomes a part-time carer for a woman with amyotrophic lateral sclerosis (ALS), which Oscar-winner Hilary will portray.
It is not known what role Josh is set to take, but he's tipped to play a love interest.
Hilary will also co-produce the movie with her 2S Films partner Molly Smith, Denise Di Novi and Alison Greenspan of DiNovi Pictures.
Josh, who appeared in all three of Michael Bay's Transformers films, will next star in ensemble comedy Movie 43 and romantic drama Safe Haven opposite Julianne Hough.