Disney and movie producer Jerry Bruckheimer have revealed they are to part ways.
The studio will end its first-look deal with the award-winning filmmaker next year, according to The Hollywood Reporter.
Their partnership started in the 90s and has produced more than 25 movies including the lucrative Pirates Of The Caribbean and National Treasure films.
The split comes soon after Bruckheimer's film The Lone Ranger, starring Johnny Depp, failed to set the box office on fire.
But Bruckheimer insisted leaving Disney had nothing to do with the film flopping.
He said: "It's time for us to tackle all kinds of movies, not just Disney movies. We're still working on Pirates and hopefully National Treasure, and we still have development at Disney."
He went on: "We have a full body of work with them. It's not about Lone Ranger. It's more about the types of movies Disney is making, and the types of movies we want to make, in addition to Pirates."
Walt Disney Studios chairman Alan Horn said: "This is about a long-term relationship with lots of pluses and minuses. The Lone Ranger certainly didn't help things, but we all have our wins and our losses, and this is an overall thing related to the company's supply of projects from all these other places."
In the statement announcing they would not be renewing their deal, Horn referred to Bruckheimer as "one of the most respected and prolific producers working in the motion picture industry".
The filmmaker - whose hits also include Top Gun and The Rock - said he was "very appreciative of the wonderful collaboration and support" he received at Disney.