The head of Pfizer in Ireland, David Gallagher, is to leave the post to head up the group's business in Australia and New Zealand. Staff at Pfizer were informed of the move this week.
Mr Gallagher, pictured, who has been the head of Pfizer's business in Ireland since 2007, will be based in Sydney.
There is no indication yet as to whether his replacement will be an Irish executive from within the Pfizer group.
Mr Gallagher has been at the helm of the US drug giant's business in Ireland during a period of intense change. He has had to strike a deal with the Government in relation to drug pricing and also tackle the impact on Pfizer's operations here as one of its biggest-selling products, cholesterol treatment Lipitor, came off patent.
Last year, Pfizer, which employs over 3,000 people in Ireland, laid off 177 workers. That included 129 at its manufacturing site in Ringaskiddy, Co Cork, and 48 at a plant in Little Island just outside Cork city. The Little Island site is used to manufacture Lipitor. Pfizer is one of the country's biggest multinational employers.