More than 120 Silicon Valley executives to attend Northern Ireland investment lunch
The firm employs more than 1,300 people in Derry.
Mr McGuinness said: "The company makes a major contribution to the economy of the north west and this is our first opportunity to meet Seagate's senior management team at its US headquarters and we look forward to it."
The ministers will also support the Cinemagic charity at a Los Angeles event, including disadvantaged young people from Northern Ireland and the US.
They will spend time in Washington DC for engagements connected with St Patrick's Day.