Jobs minister Richard Bruton is to lead a five-day US investment mission.
It will target more than 20 world-leading companies in financial services, life-sciences and technology and involves one-on-one meetings with companies employing a total of 1.5 million people worldwide and with combined annual revenues of over 400 billion euro.
The delegation will visit New York and Boston.
Mr Bruton said: "A key part of the Government's plans for jobs and growth is to attract more international companies to invest in Ireland. Through the Action Plan for Jobs, we are continuing to improve our competitiveness, to improve our skills, and to undertake a very intensive programme of trade and investment missions.
"The multinational sector has performed very well recently after a very challenging three years between 2008 and 2010."
The minister added: "This has made a major contribution to the positive trends we are now seeing with over 3,000 jobs being added every month across the private sector, compared to the 7,000 that were being lost every month before we took office."