Mr Romney is hoping to undo a string of foreign policy stumbles, taking aim at an issue where polls show Mr Obama holds a clear lead.
Saying there is, "a longing for American leadership in the Middle East," Mr Romney called for the US to take a more assertive role in Syria. He also wants new conditions on aid to Egypt and would impose tighter sanctions on Iran.
With the race growing tighter after Mr Obama's poor performance in last week's presidential debate Democrats and Republicans now are looking to Thursday's debate confrontation between vice president Joe Biden and Republican Paul Ryan.
Both sides are bearing down on their attempts to draw in the small percentage of voters who remain undecided in fewer than 10 states, with Iowa, Ohio, Virginia and Florida all set for candidate visits this week.
Mr Romney intends his foreign policy speech as a vehicle to send tough signals on Iran and Syria and portray Mr Obama as weak for his administration's changing explanation for the deadly attacks on the US consulate in Libya.
The Obama campaign was hitting back in advance. "We're not going to be lectured by someone who has been an unmitigated disaster on foreign policy," a campaign spokeswoman said.
Voters give Mr Obama higher marks than Mr Romney on questions of national security and crisis response, but world affairs in general are a distant priority compared with the struggling US economy, polling shows. Nevertheless, Mr Romney will broaden his explanation of how he would serve as commander in chief.
After polls recently suggested Mr Obama had narrow leads in several swing states, the Romney campaign says the race is tightening following his strong performance in last week's debate. To help maintain his momentum, Mr Romney has tweaked his message over the last week, highlighting his compassionate side and centrist political positions.
Mr Obama engaged in a bit of self-deprecation in his latest appearance, taking a good-natured shot at his own underwhelming debate performance last week, marvelling at how his friends in the entertainment business could turn in flawless showings every time. "I can't always say the same," Mr Obama said of his debate performance, compared to those of his entertainment business friends. He spoke to thousands of supporters who got the joke. It was his most direct acknowledgment that Mr Romney won their debate as the campaign entered its final month.