The 23-year-old pulled out of the England squad for the midweek friendly in Sweden after suffering an injury to his buttock muscles in last week's 3-3 draw against Fulham. Arsenal will also assess goalkeeper Wojciech Szczesny, who could be back in the side for the first time since September after recovering from an ankle problem, while midfielder Alex Oxlade-Chamberlain is another who will be monitored.
He added: "It is just for general fatigue. Sagna has played three games quickly, but before that he didn't play for six months."
Midfielder Jack Wilshere should come back into the side after he was suspended for the Fulham game, provided he shows no ill effects from his England appearance in Stockholm, where full-back Carl Jenkinson made his debut, also as a second-half substitute.
"I believe he didn't need games," Wenger told Arsenal Player. "He was overloaded with games so on that front I was happy that he got a little breather.
"It is not a complete breather because 20 hours travelling is of course not what we want. It's the advantage and the disadvantage of being called up in a squad. At least he didn't get injured and hopefully will recover before Saturday."