Manchester United winger Nani has been ruled out for 10 days with a hamstring injury.
Central defender Jonny Evans is struggling with a groin injury for this weekend's match, which could mean a second game in four days for Chris Smalling.
"Jonny is a doubt," said Ferguson. "It is not a serious one. We are monitoring it and hopefully he will be OK."
If recent history is anything to go by, United should not be too inconvenienced given they have recorded 10 wins and six draws in the 16 years since their last Premier League defeat at Villa Park, in 1995.
It seems strange to think now the Midlands giants were the side United edged out to win their first title of the Ferguson era in 1993.
"It is a daunting task to bring Aston Villa back to where everyone expects them to be," said Ferguson. "They have a great history. They won the European Cup in 1981. It is correct to say they have not matched their expectations over the years.
"You wonder whether changing managers has a bigger impact than the actual playing standards of the team. They have had quite a few managers and it takes time to change a team's fortunes."