The Argentinian remains on the sidelines for this weekend's trip to Arsenal after tearing a hamstring in the New Year's Day victory over Stoke at the Etihad Stadium. There has been speculation the 24-year-old could be out for several weeks but the club have not put a firm date on his potential comeback.
He added: "If Arsenal was the last game (of the season), okay, but like this it is impossible."
Aguero, top scorer with 30 goals last season, made a slow start to the current campaign after suffering a knee injury in the opening game against Southampton.
But he looked back to his best as he took his tally for the season to 10 with goals in his last two appearances before limping off against the Potters.
He said: "Sergio is out for one game but this doesn't change (anything) because we have another three strikers.
"We can change our system any moment, not because we are missing Sergio or other players."